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Hypertension Animal Model (CAT#: STEM-AE-0048-WXH)

Introduction

Hypertension refers to an increase in systemic arterial blood pressure (systolic blood pressure and/or diastolic blood pressure) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney and other organ functions or clinical syndrome of organic damage. Hypertension is the most common chronic disease and the main risk factor for cardiovascular and cerebrovascular diseases. The animal model of hypertension is a model used in the research of hypertensive diseases and their complications, which can be divided into two kinds of animal models: spontaneous hypertension and induced hypertension.




Applications

• Study the pathogenesis and treatment of hypertension.
• Drug development, drug screening and efficacy research.

Procedure

• Induced hypertension model:
1. Renal artery stenosis: Use a silver clip or ring to cover the renal artery after anesthesia.
2. Extrarenal bandaging type: extrarenal foreign body bandaging.
3. Auditory hypertension model: make rats exposed to noise stimulation for a long time.
• Spontaneous hypertension model: SHR rats, etc..

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