Study of Mechanical Characterization of 3D Ovarian Cancer Nodules Using Brillouin Scattering (CAT#: STEM-ST-0130-YJL)

Introduction

Improvements in outcomes for advanced stage ovarian cancer (OvCa) continue to lag behind many other solid tumors with a 5-year survival rate of 45%, which is further reduced to 31% after 10 years. Furthermore, cell populations exhibit heterogeneity with varying levels of proliferation, invasiveness and resistance to chemother- apy. In recent years, a relationship between OvCa aggressiveness and mechanical properties was observed, providing evidence that mechanical adapta- tion contributes to cell migration and survival. The mechanical interaction between cells and their microenvironment is emerging as an important determinant of cancer progression and sensitivity to treatment, including in ovarian cancer (OvCa).

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Principle Applications Procedure Materials Notes Related Products

Principle

From a quantum point of view, Brillouin scattering is an interaction of light photons with acoustic or vibrational quanta (phonons), with magnetic spin waves (magnons), or with other low frequency quasiparticles interacting with light. The interaction consists of an inelastic scattering process in which a phonon or magnon is either created (Stokes process) or annihilated (anti-Stokes process). The energy of the scattered light is slightly changed, that is decreased for a Stokes process and increased for an anti-Stokes process. This shift, known as the Brillouin shift, is equal to the energy of the interacting phonon and magnon and thus Brillouin scattering can be used to measure phonon and magnon energies.

Applications

Brillouin scattering is used to determine acoustic velocities and elastic properties of a number of crystalline solids, glasses, and liquids.

Procedure

1. Sample preparation
2. Measurement by scattering detection instrument
3. Data analysis

Materials

Brillouin scattering measurement system (Brillouin spectrometer)

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