Whole Brain Fine Imaging Technique to study brain function (CAT#: STEM-PET-0020-WXH)

Introduction

Micro-Optical sectioning tomography (MOST) system is a whole-brain imaging system based on mechanical cutting. Tissue was excised, and new surfaces continued to be imaged, culminating in the acquisition of a complete mouse brain dataset with 1 µm axial resolution.<br />To understand the mechanism of brain function, it is necessary to obtain the complete morphology of neurons and the structural map of neurons in the whole brain. Therefore, it is very important to develop methods for fine imaging of the whole brain. The working principle of whole-brain imaging is similar to using satellites to scan the earth in a panoramic manner, and its spatial resolution accuracy reaches sub-micron level, which is less than 1/60 of the thickness of a human hair. Using optical imaging methods, not only local neural connections can be seen, but also the three-dimensional "roads" and "railways" that construct neural networks can be observed in the whole brain.