WeSPR Cell Analyzer SP Real-Time Label-Free Cellular Analysis System

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WeSPR Cell Analyzer SP

Insight Into Living Cells

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WeSPR Cell Analyzer SP Real-Time Label-Free Cellular Analysis System (STEMart Original)

The WeSPR Cell Analyzer SP is a compact, high-throughput live cell analysis platform designed for real-time, label-free, and non-invasive monitoring of cellular behavior. Utilizing a 96-well plate format, the system enables parallel measurement of cell states across all wells, providing a complete and efficient solution for cell biology research.

With its ability to be seamlessly integrated inside standard incubators, the system ensures uninterrupted cell growth during monitoring—eliminating the need to repeatedly open and close incubator doors and thereby minimizing environmental disturbances. This makes it possible to continuously track cellular events for days to weeks with full automation.

Principle

The system is based on a patented microplate design in which the well bottoms function as nano metasurface SPR biosensors. Subtle changes in transmitted optical signals are measured in real time, allowing non-destructive tracking of key cellular processes such as:

Cell proliferation
Adhesion and spreading
Morphological changes
Migration and differentiation

By combining imaging-based live cell monitoring with precision biosensing, the WeSPR Cell Analyzer SP delivers rich information about cell dynamics, functionality, and responses to external stimuli.

Live Cell Imaging And Real-Time Analysis Of Cell Proliferation Using the WeSPR Cell Analyzer SP (STEMart Original)

Features

High-Throughput Microplate Design: 96 wells measured in parallel; co-culture of multiple cell types in a single run.

Uninterrupted Environment: Continuous monitoring inside an incubator without disturbing cells, ensuring accurate and reproducible results.

Non-Invasive, Label-Free Analysis: Real-time tracking of cellular states over days or weeks with no sample loss.

Automated and User-Friendly: Guided software with one-click operation and full automation, reducing hands-on time and complexity.

Compact and Compatible: Small footprint design, seamlessly integrates with most incubator brands.

SPR-Based, Not Impedance-Based: Unlike RTCA impedance systems, it avoids external electrical interference with cell growth.

WeSPR Cell Analyzer SP Features (STEMart Original)

Application Examples

1. Real-Time Monitoring of Cell Proliferation

Track adhesion and growth of adherent cells in real time, generating continuous proliferation curves. Results align with gold-standard CCK8 assays, helping optimize culture protocols and experimental timing.

Illustration of Real-Time Monitoring of Cell Proliferation Using the WeSPR Cell Analyzer SP (STEMart Authorized)

2. Cell Viability and Drug Response

Assess cytotoxicity and therapeutic effects dynamically. For example, SNU-16 gastric cancer cells treated with different concentrations of oxaliplatin showed dose-dependent viability changes, guiding drug efficacy evaluation and treatment optimization.

Illustration of Cell Viability and Drug Response Using the WeSPR Cell Analyzer SP (STEMart Authorized)

3. Cell Adhesion and Spreading

Quantify adhesion and spreading dynamics using reagents such as poly-L-lysine. This enables rapid screening of adhesion-promoting reagents and deeper insights into cell regulation mechanisms.

Illustration of Cell Adhesion and Spreading Using the WeSPR Cell Analyzer SP (STEMart Authorized)

4. NK Cell-Mediated Cytolysis

Evaluate immune cell-mediated killing in real time. By co-culturing HL-60 target cells with NK92 effector cells at varying ratios, researchers can analyze tumor cell killing efficiency and optimize immunotherapy protocols.

Illustration of NK Cell-Mediated Cytolysis Using the WeSPR Cell Analyzer SP (STEMart Authorized)

The WeSPR™ Cell Analyzer SP provides a powerful, fully automated platform for continuous, real-time, label-free analysis of live cells. Its unique combination of high-throughput 96-well compatibility, incubator integration, and non-invasive SPR-based sensing makes it an ideal solution for cell biology research, oncology, immunology, and drug development.