WeSPR 200
Precision Enhanced by Temperature
The WeSPR 200 is an advanced, high-throughput, flow-free molecular interaction analyzer equipped with an integrated temperature control module. Built on MetaSPR (Metasurface Plasmon Resonance) technology, it provides label-free, real-time biomolecular interaction analysis with improved sensitivity and reproducibility.
Designed to handle both purified and complex biological samples, the WeSPR 200 delivers reliable kinetic, affinity, epitope, and quantitative analysis while minimizing preprocessing. With its compact footprint, parallel channel capacity, and precise thermal regulation, the system enhances assay consistency and supports a broad spectrum of research applications.
Temperature Control Module: Enables precise incubation and analysis across a wide range of experimental conditions.
Parallel Analysis: Supports up to 8 optical channels and dual 96-well plates for high-throughput workflows.
Versatile Applications: Provides kinetic/affinity profiling, fragment screening, epitope mapping, immunogenicity testing, thermodynamic analysis, quantitative assays, and ELISA-equivalent functions.
Broad Sample Compatibility: Compatible with complex matrices as well as purified biomolecules, reducing preparation time.
Flow-Free Design: Eliminates fluidic maintenance, ensuring straightforward and reliable operation.
Enhanced Sensitivity: Low baseline noise and drift deliver higher data quality for challenging samples.
| Parameter | Specification |
|---|---|
| Automation Level | Semi-automated |
| Optical Channels | 8 independent fiber-optic detection channels |
| Applications | Kinetics & affinity characterization, screening, single-cycle kinetics, small molecule interaction analysis, fragment-based screening, epitope mapping & pairing, immunogenicity, quantitative analysis, thermodynamics, ELISA and microplate reader functions |
| Refractive Index Range | 1.33–1.43 |
| Sample Volume | 2–200 μL, non-destructive |
| Incubation Function | Supported |
| Temperature Range | RT+4 to 50 °C |
| Shaking Speed | 200–1200 rpm |
| Data Display | Real-time binding curves, curve fitting, calibration curves, concentration tables, kinetic data tables, epitope mapping plots, bar charts |
| Data Export Formats | Excel, TXT |
| Sample Types | Small molecules, peptides, proteins, antibodies, nucleic acids, polysaccharides, lipids, cells, viruses, and complex matrices (DMSO buffers, serum, plasma, supernatants, lysates) |
| Throughput | Up to 8 parallel analyses; maximum 96 samples per run |
| Buffer Selection | Dual buffer switching |
| Association Rate Constant (ka) | Proteins: 10¹–10⁷ M⁻¹s⁻¹; Small molecules: 10³–5×10⁷ M⁻¹s⁻¹ |
| Dissociation Rate Constant (kd) | 10⁻⁶–10⁻¹ s⁻¹ |
| Affinity Range (KD) | pM–mM |
| Minimum Detectable Mass | 200 Da |
| Analysis Time | <10 min for 8-sample affinity tests; up to 12h for real-time kinetic assays; maximum 96-sample screening with minimum 5 min run time, data sorted by binding signal |
| Baseline Noise (RMS) | <0.005 RU |
| Baseline Drift | <0.001 RU/hour |
| Quantitative Throughput | Up to 96 samples simultaneously |
| Concentration Range | 0.005–1000 μg/mL |
The WeSPR 200 extends the performance of the WeSPR platform by combining high-throughput capability with precision temperature control, ensuring consistent and sensitive biomolecular interaction data. Its flow-free design, compatibility with complex samples, and broad application coverage make it an ideal choice for researchers working on drug discovery, antibody development, vaccine research, and molecular mechanism studies.
Contact us today to learn how WeSPR 200 can elevate your molecular interaction analysis with higher sensitivity and reproducibility.
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