SP Seplife XL Strong Cation-Exchange Medium, 160 mg Lysozyme/mL (CAT#: STEM-BC-3154-ZJF)

This strong cation-exchange medium is designed for downstream purification of proteins, nucleic acids, and peptides. It uses highly crosslinked agarose microspheres grafted with dextran tentacles. Sulfopropyl groups are coupled to the extended dextran chains. The tentacle structure increases the accessible binding area and provides very high capacity. A lysozyme adsorption capacity of 160 mg/mL supports productive capture operations. The medium combines high flow with relatively low backpressure. Low nonspecific adsorption contributes to product recovery and process reproducibility. Broad chemical stability supports exposure to common buffers, detergents, denaturants, and alkaline cleaning solutions. The resin can be scaled from process development to manufacturing columns.

Model: SP Seplife XL
Appearance: White spherical gel, odorless and tasteless
Type: Strong cation-exchange medium
Matrix: Seplife XL microspheres with dextran tentacles
Ligand: Sulfopropyl
Particle size: 45-165 µm
Lysozyme adsorption capacity: 160 mg/mL
Ion-exchange capacity: 0.18-0.25 mmol/mL
Flow range: 300-500 cm/h
Pressure resistance: 0.3 MPa
Operating temperature: 4-40°C
Long-term pH stability: 4-13
Short-term CIP pH stability: 3-14
Chemical compatibility: Common aqueous buffers, nonionic detergents, 6 mol/L guanidine hydrochloride, 1 mol/L sodium hydroxide, and 20% ethanol

Dextran-tentacle architecture
Very high lysozyme capacity
Strong sulfopropyl exchange
High-flow operation
Low backpressure
Low nonspecific adsorption
Broad chemical compatibility
Scalable downstream purification

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