Seplife LXPM SP400M Strong Cation-Exchange Medium, 4000 Å (CAT#: STEM-BC-3104-ZJF)

This strong cation-exchange medium is designed for purification and primary fractionation of large biological molecules. It uses a polymethyl methacrylate matrix with a hydrophilic surface modification. Sulfonic-acid groups provide strong cation-exchange functionality. The 4000 Å pore structure is intended to improve access for proteins, antigens, and other macromolecules. Uniform pore channels and rigid particles support stable chromatographic performance. The medium provides lower backpressure than many conventional soft-gel media. A lysozyme binding capacity of at least 75 mg/mL supports preparative processing. The resin can be regenerated with salt and cleaned using sodium hydroxide or ethanol.

Model: Seplife® LXPM SP400M
Matrix: Polymethyl methacrylate
Appearance: White opaque spherical particles
Functional group: -R-SO3-
Ion-exchange type: Strong cation exchange
Exchange capacity: 0.06-0.10 mmol/mL
Average particle size: 80 µm
Pore size: 4000 Å
Binding capacity: ≥75 mg lysozyme/mL
Pressure-flow range: 120-300 cm/h
Long-term pH range: 2-13
Short-term pH exposure: pH 1 or 14 for ≤100 h
Maximum pressure: 0.8 MPa
Storage: 20% ethanol at 4-30°C
Regeneration: 0.5-2 M sodium chloride
Cleaning: 0.1-0.5 M sodium hydroxide or 50% ethanol

Large 4000 Å pores
Strong cation-exchange chemistry
Designed for biomacromolecules
Low-backpressure rigid matrix
≥75 mg/mL lysozyme capacity
Wide pH tolerance
Salt-regenerable medium
Alternative to soft agarose resins

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