Seplife LXPM Q400M Strong Anion-Exchange Medium, ≥180 mg/mL (CAT#: STEM-BC-3105-ZJF)

This strong anion-exchange medium is designed for purification of proteins, antigens, and other biological macromolecules. It uses a hydrophilically modified polymethyl methacrylate matrix. Quaternary amine groups provide strong anion-exchange binding. The 4000 Å pores improve access for large molecules and protein aggregates. Uniform pore channels and rigid particles provide stable separation performance. The medium combines high mechanical strength with relatively low backpressure. Its stated binding capacity reaches at least 180 mg/mL with lysozyme as the reference analyte. The material can be regenerated using sodium chloride and cleaned with sodium hydroxide or ethanol.

Model: Seplife® LXPM Q400M
Matrix: Polymethyl methacrylate
Appearance: White opaque spherical particles
Functional group: -R-N+(CH3)3
Ion-exchange type: Strong anion exchange
Exchange capacity: 0.10-0.14 mmol/mL
Average particle size: 80 µm
Pore size: 4000 Å
Binding capacity: ≥180 mg lysozyme/mL
Pressure-flow range: 120-300 cm/h
Long-term pH range: 2-13
Short-term pH exposure: pH 1 or 14 for ≤100 h
Maximum pressure: 0.8 MPa
Storage: 20% ethanol at 4-30°C
Regeneration: 0.5-2 M sodium chloride
Cleaning: 0.1-0.5 M sodium hydroxide or 50% ethanol

Very high ≥180 mg/mL capacity
Large 4000 Å pore structure
Strong quaternary-amine exchange
Rigid low-backpressure matrix
Suitable for large biomolecules
Broad pH tolerance
Regenerable with salt
Supports aggregate purification

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