Seplife LXPM DEAE400M Weak Anion-Exchange Medium, 4000 Å (CAT#: STEM-BC-3106-ZJF)

This weak anion-exchange medium is designed for separation and purification of proteins, antigens, and other large biomolecules. It uses a hydrophilically modified polymethyl methacrylate matrix. Diethylaminoethyl groups provide weak anion-exchange selectivity. The 4000 Å pore structure improves accessibility for macromolecules and aggregates. Uniform pores and strong mechanical properties support stable packed-bed operation. The material provides relatively low backpressure during preparative processing. A stated lysozyme binding capacity of at least 80 mg/mL supports large-scale purification. The medium can be regenerated with salt and cleaned using sodium hydroxide or ethanol.

Model: Seplife® LXPM DEAE400M
Matrix: Polymethyl methacrylate
Appearance: White opaque spherical particles
Functional group: -O-(CH2)2-HN+-(C2H5)2
Ion-exchange type: Weak anion exchange
Exchange capacity: 0.18-0.22 mmol/mL
Average particle size: 80 µm
Pore size: 4000 Å
Binding capacity: ≥80 mg lysozyme/mL
Pressure-flow range: 120-300 cm/h
Long-term pH range: 2-13
Short-term pH exposure: pH 1 or 14 for ≤100 h
Maximum pressure: 0.8 MPa
Storage: 20% ethanol at 4-30°C
Regeneration: 0.5-2 M sodium chloride
Cleaning: 0.1-0.5 M sodium hydroxide or 50% ethanol

Weak DEAE exchange selectivity
Large 4000 Å pores
≥80 mg/mL binding capacity
Rigid polymeric matrix
Low operating backpressure
Broad pH tolerance
Salt-regenerable medium
Suitable for protein aggregate processing

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