Seplife LXMS 50S Strong Cation-Exchange Medium, ≥102 mg h-IgG/mL (CAT#: STEM-BC-3108-ZJF)

This strong cation-exchange medium is designed for purification of antibodies, recombinant proteins, vaccines, blood products, viruses, DNA, and peptides. It uses a porous polystyrene-divinylbenzene matrix with a hydrophilic surface treatment. Sulfonic-acid ligands provide strong cation-exchange functionality. The hydrophilic surface reduces nonspecific adsorption during chromatographic processing. The rigid polymeric matrix supports operation at high pressure and high linear flow. High resolution improves impurity removal and product recovery. Salt tolerance provides flexibility in process development and reduces the need for extensive feed dilution. The high dynamic binding capacity can reduce packed-bed volume, buffer consumption, and cycle count. The medium is suitable for capture, intermediate purification, and polishing operations.

Model: Seplife® LXMS 50S
Appearance: White opaque spherical particles, odorless and tasteless
Type: Strong cation-exchange medium
Matrix: Polystyrene-divinylbenzene
Ligand: Sulfonic-acid group
Median particle size d50v: 50 µm
Pressure-flow range: 200-800 cm/h
Long-term pH stability: 2-12
Short-term CIP pH stability: 1-14
Chemical compatibility: Common ion-exchange buffers
Ion-exchange capacity: 0.16-0.20 mmol/mL
Dynamic binding capacity: ≥102 mg human IgG/mL
Maximum pressure: 30 bar
Test conditions: 10 cm bed height, 25°C, and 0.1 mol/L sodium chloride

High h-IgG binding capacity
Strong sulfonic-acid exchange
Rigid 30-bar matrix
High-flow operation
Hydrophilic low-binding surface
Broad CIP pH range
Salt-tolerant processing
High chromatographic resolution

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