Seplife LXMS 50HS Strong Cation-Exchange Medium, ≥70 mg Lysozyme/mL (CAT#: STEM-BC-3109-ZJF)

This strong cation-exchange medium is designed for purification of monoclonal antibodies, recombinant proteins, vaccines, blood products, viruses, DNA, and peptides. It uses a porous polystyrene-divinylbenzene polymer matrix. Sulfonic-acid groups provide strong cation-exchange binding. The rigid matrix supports operation at elevated pressure and high flow while maintaining low backpressure. High salt tolerance expands the usable feed-conductivity range. This property can reduce dilution, dialysis, and ultrafiltration buffer-exchange requirements. The medium provides high resolution and stable protein-binding capacity. Its physical and chemical stability supports linear process scale-up. The product is suitable for capture, intermediate purification, and polishing applications.

Model: Seplife® LXMS 50HS
Appearance: White opaque spherical particles, odorless and tasteless
Type: Strong cation-exchange medium
Matrix: Polystyrene-divinylbenzene
Ligand: Sulfonic-acid group
Median particle size d50v: 50 µm
Pressure-flow range: 200-800 cm/h
Long-term pH stability: 2-12
Short-term CIP pH stability: 1-14
Chemical compatibility: Common ion-exchange buffers
Ion-exchange capacity: 0.10-0.14 mmol/mL
Dynamic binding capacity: ≥70 mg lysozyme/mL
Maximum pressure: 30 bar
Test conditions: 10 cm bed height, 25°C, and 0.1 mol/L sodium chloride

High salt tolerance
Strong cation-exchange chemistry
Low operating backpressure
High-flow rigid particles
Stable protein capacity
Broad CIP pH range
Reduced feed-dilution requirements
Linear scale-up capability

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