Recombinant Human TGF-β2 Protein, Seafrom (CAT#: STEM-CT-0033-ZJF)

The Recombinant Human TGF-β2 Protein manufactured by Seafrom is suitable for tissue development, cell differentiation, and regeneration.
Transforming Growth Factor-beta (TGF-β), including its isoforms TGF-β1, β2, and β3, signal through the same receptor, inducing similar biological responses. These multifunctional cytokines regulate cell proliferation, growth, differentiation, motility, and extracellular matrix synthesis and deposition. They play pivotal roles in various physiological processes, such as embryogenesis, tissue remodeling, and wound healing. Typically, they are secreted primarily as latent complexes and are stored on the cell surface and within the extracellular matrix. The release of bioactive TGF-β isoforms from latent complexes involves conformational changes induced by proteolysis, complex processing, and/or thrombospondin-1, among other protein-related conformational alterations. TGF-β2 exerts inhibitory effects on the growth of IL-2-dependent T cells and may play an autocrine role in suppressing tumor growth through the inhibition of immune surveillance.
The lyophilized product can be stored at 4°C for 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, with caution to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC1, Cetermin, Polyergin
Protein Sequence: DNA sequence encodes human TGF-β2 (UniProtKB-P61812) with an Fc tag at the C-terminus, predicted molecular weight of 42.1 kD
Purity: ≥95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: ≤0.01 EU/μg (gel clot method)
Biological Activity: ED50 determined by the ability to inhibit the proliferation of mouse HT-2 cells dependent on IL-4 is ≤0.5 ng/mL
Purification Method: Chromatographic purification

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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