Recombinant Human PDGF-AA Protein, Seafrom (CAT#: STEM-CT-0078-ZJF)

The Recombinant Human PDGF-AA Protein manufactured by Seafrom is suitable for stimulating cell proliferation and tissue repair.
PDGFs (Platelet-Derived Growth Factors) are dimers composed of two 12.0-13.5 kDa polypeptide chains, referred to as PDGF-A and PDGF-B chains, linked by disulfide bonds. The three naturally occurring PDGF forms, PDGF-AA, PDGF-BB, and PDGF-AB, are potent mitogens for various cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, as well as certain blood cells. PDGFs are stored in platelet alpha-granules and released upon platelet activation. PDGFs play roles in numerous biological processes, including proliferation, chemotaxis, embryonic neuronal development, and the development of respiratory epithelial cells. Two distinct signaling receptors for PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three forms of PDGF, while PDGFR-β interacts only with PDGF-BB and PDGF-AB.
The lyophilized form can be stored at 4°C for 24 months, and the reconstituted liquid can be stored at -20°C for 6-12 months, avoiding repeated freeze-thaw cycles. For reconstitution, you can use injection-grade water, saline, culture medium, or PBS. After reconstitution (dilution), it is recommended to maintain a concentration of at least 100 μg/mL.

Expression Host: HEK-293 Cells
Molecular Weight: Recombinant human PDGF-AA protein contains 358 amino acids, predicted molecular weight of 41.2 kD.
Purity: >95%, analyzed by SDS-PAGE and HPLC.
Endotoxin Level: <0.1 EU/μg.
Biological Activity: ED50 determined by dose-dependent stimulation of BALB/C 3T3 cells for adenosine absorption, with a value of ≤ 2 ng/mL.
Purification Method: Chromatographic purification.
Appearance: White loose body.

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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