Recombinant Human OX40 Ligand Protein, Seafrom (CAT#: STEM-CT-0097-ZJF)

The Recombinant Human OX40 Ligand Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
Similar to other members of the TNF superfamily, membrane-bound OX40 ligand exists in the form of homotrimer. OX40 ligand protein is the ligand for OX40/CD134 and is expressed on antigen-presenting cells, activated T cells, and other cells, including lymphoid tissue inducer cells, some endothelial cells, and mast cells. It can also promote Th2 cell differentiation. OX40 ligand protein is involved in the pathogenesis of various autoimmune and inflammatory diseases, such as systemic lupus erythematosus (SLE), carotid artery disease, and cancer. The interaction between OX40 and OX40 ligand has been proposed as a potential therapeutic target for autoimmune diseases.
The lyophilized product can be stored at 2-8°C for 24 months. If needed to be aliquoted, it can be dissolved in injection-grade water, saline, culture medium, or PBS. After dissolution, it can be divided into small portions and stored at -20°C for 6 months or -80°C for 12 months. The concentration after dilution should not be less than 100μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Synonyms: OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1
Protein Sequence: The DNA sequence encodes human OX40 Ligand (NCBI Reference Sequence: NP_003317.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human OX40 Ligand protein consists of 364 amino acids, with a predicted theoretical molecular weight of 42.4 kD.
Purity: >90%, confirmed by SDS-PAGE gel analysis
Endotoxin: <0.1 EU/μg
Biological Activity: Determined by its ability to induce IL-8 secretion from human PBMC cells, with an ED50 ≤ 100 ng/mL.
Purification Method: Chromatographic purification
Appearance: White, loose powder

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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