Recombinant Human Oncostatin M Protein, Seafrom (CAT#: STEM-CT-0115-ZJF)

The Recombinant Human Oncostatin M Protein manufactured by Seafrom is suitable for immune regulation and cell growth.
Oncostatin M, also known as OSM, is a glycoprotein that belongs to the interleukin-6 cytokine family and primarily functions in cell growth. Among these cytokines, it structurally and functionally resembles Leukemia Inhibitory Factor (LIF). However, its precise role is not yet clearly defined, but it has been shown to be important in liver development, hematopoiesis, inflammation, and potentially central nervous system development. It is also associated with bone formation and resorption. OSM signals are transmitted through cell surface receptors containing the protein gp130. The type I receptor is composed of gp130 and LIFR, while the type II receptor consists of gp130 and OSMR.
Oncostatin M (OSM) has previously been demonstrated to have the ability to inhibit the growth of melanoma and other solid tumor cells. It has also been reported that, similar to LIF, IL-6, and G-CSF, OSM can inhibit the proliferation of mouse M1 myeloid leukemia cells and induce their differentiation into macrophage-like cells. The human form of OSM is insensitive to pH levels between 2 and 11, can be heated for 1 hour at 56 degrees Celsius but is unstable at 90 degrees Celsius. The three-dimensional structure of human OSM has been resolved at atomic resolution, confirming the predicted long-chain four-helix bundle topology. When compared to the known structures of other LC cytokines, it is most closely related to LIF.
Storage Information:
Lyophilized samples can be stored at 2-8°C for 24 months, and once reconstituted, the liquid can be stored at -20°C for 6-12 months, with care taken to avoid repeated freeze-thaw cycles. It can be dissolved (diluted) in injection water, saline, culture medium, or PBS. The recommended concentration after dilution should be maintained above 100ug/mL.

Expression Host: Human HEK293 cells
Synonyms: OSM, MGC20461
Molecular Weight: Recombinant human Oncostatin M protein contains 227 amino acids, with a predicted theoretical molecular weight of 27.5 kD.
Purity: >95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Analyzed for cell proliferation using human TF-1 cells, with an ED50 of 2-10 ng/mL.
Purification Method: Chromatographic purification
Appearance: White loose powder

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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