Recombinant Human IL-15 Protein, Seafrom (CAT#: STEM-CT-0021-ZJF)

The Recombinant Human IL-15 Protein manufactured by Seafrom is suitable for proliferation, activation, and survival of T cells and NK cells.
Interleukin-15 (IL-15) is a cytokine with a structure similar to IL-2. Like IL-2, IL-15 signals through a complex consisting of the IL-2/IL-15 receptor β chain (CD122) and the common gamma chain (gamma-c, CD132). IL-15 is secreted by monocytes and macrophages, among other cells, typically in response to viral infections. IL-15 can regulate the activation and proliferation of T cells and natural killer (NK) cells. Recombinant human IL-15 protein is a modified form of human IL-15 with increased stability, enhanced activity, an extended half-life, and prolonged potency.
The lyophilized formulation can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injection-grade water, physiological saline, culture medium, or PBS. After dissolution, it should be divided into smaller aliquots and stored at -20°C for 6 months or at -80°C for 12 months, with a final concentration after dilution not lower than 100 μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Interleukin-15, MGC9721
Protein Sequence: DNA sequence encodes human IL-15 (P40933) and IL-15RA (Q13261) with an Fc tag at the C-terminus, predicted molecular weights of 12.8 kD and 33 kD
Purity: >95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: <0.01 EU/μg
Biological Activity: Cell proliferation assay using CTLL-2 cells, ED50 is 0.2-3 ng/mL, corresponding specific activity is >5x10^6 IU/mg (calibrated against human IL-15 reference standard, NIBSC code: 95/554)
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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