Recombinant Human IL-10 Protein, Seafrom (CAT#: STEM-CT-0083-ZJF)

The Recombinant Human IL-10 Protein manufactured by Seafrom is suitable for studying anti-inflammatory effects and immune regulation.
Interleukin-10 (IL-10) is an immunosuppressive cytokine produced by various mammalian cell types, including macrophages, monocytes, T cells, B cells, and keratinocytes. IL-10 inhibits the expression of pro-inflammatory cytokines such as IL-1 and TNF-α. Similar to IL-4, IL-10 enhances humoral immune responses while dampening cell-mediated immune responses. Human interleukin-10 is active on mouse cells, while mouse interleukin-10 is not active on human cells.
The lyophilized form can be stored at 4°C for 24 months. If reconstitution is necessary, it can be dissolved in injection-grade water, saline, culture medium, or PBS. After reconstitution, it should be aliquoted and stored at -20°C for 6-12 months, while avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: B-TCGF, CSIF, TGIF, IL-10, IL10A, GVHDS, MGC126450, MGC126451, RP11-262N9.1, Interleukin-10
Protein Sequence: DNA sequence encodes human IL-10 (NP_000563.1) with a His tag at the C-terminus, contains 166 amino acids, predicted molecular weight of 19.5 kD.
Purity: ≥95%, analyzed by SDS-PAGE and HPLC.
Endotoxin Level: <0.1 EU/μg (gel clot method).
Biological Activity: Determined by dose-dependent stimulation, in combination with human interleukin 4 (IL-4), of MC/9 cells; ED50 is ≤ 2.0 ng/mL, corresponding to specific activity ≥ 5×10^5 IU/mg.
Purification Method: Chromat

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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