Recombinant Human IFN-λ1 Protein, Seafrom (CAT#: STEM-CT-0064-ZJF)

The Recombinant Human IFN-λ1 Protein manufactured by Seafrom is suitable for antiviral and immunomodulatory effects.
Interferon lambdas 1, 2, and 3 (known as IL-29, IL-28A, and IL-28B, respectively) are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system consisting of the IFN-λR1 subunit (also known as CRF 2-12) and the IL-10R2 subunit (also known as CRF 2-14). Signaling through this receptor system can induce antiviral defense similar to Type I interferons but distinct from Type I interferons. Recombinant human IFN-λ1 is a protein with 178 amino acid residues and a molecular weight of 19.8 kDa.
The lyophilized formulation can be stored at 4°C for 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, while avoiding repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: IL-29
Protein Sequence: DNA sequence encodes human IFN-λ1 (NP_742152.1) with a His tag at the C-terminus, contains 184 amino acids, predicted molecular weight of 20.6 kD
Purity: ≥95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: ≤0.01 EU/μg (gel clot method)
Biological Activity: Depends on its ability to activate STAT phosphorylation, analyzed in ISRE luciferase reporter assay using human colorectal cancer COLO205 cells, ED50 is 0.2-0.5 ng/mL
Purification Method: Chromatographic purification

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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