Q Seplife FF Strong Anion-Exchange Medium,>55 mg BSA/mL (CAT#: STEM-BC-3075-ZJF)

This strong anion-exchange medium is designed for downstream purification of proteins, nucleic acids, and peptides. It uses a highly crosslinked agarose matrix functionalized with quaternary ammonium groups. The spherical gel structure supports high flow with low backpressure. High binding capacity supports productive capture and intermediate purification operations. Low nonspecific adsorption contributes to product recovery and process consistency. The medium provides chemical and mechanical stability during repeated processing. A broad cleaning-in-place pH range supports regeneration between purification cycles. The medium can be scaled from process development to larger manufacturing columns. Steam exposure at the stated conditions is supported for compatible process requirements.

Model: Q Seplife FF
Appearance: White spherical gel, odorless and tasteless
Type: Strong anion-exchange medium
Matrix: Seplife 6FF
Ligand: Trimethylaminoalkyl quaternary ammonium group
Particle size: 45-165 µm
Long-term pH stability: 2-12
Short-term CIP pH stability: 1-14
Chemical compatibility: Common aqueous buffers, 1 mol/L sodium hydroxide, 8 mol/L urea, 8 mol/L guanidine hydrochloride, and 70% ethanol
Adsorption capacity:>55 mg BSA/mL
Ion-exchange capacity: 0.18-0.25 mmol/mL
Operating temperature: 4-40°C
Heat resistance: 121°C in water for 30 min
Maximum flow rate: 750 cm/h
Pressure resistance: 0.3 MPa
Flow-test conditions: 15 cm bed height, 25°C, and 0.1 mol/L sodium chloride

Strong anion-exchange chemistry
High BSA binding capacity
Up to 750 cm/h flow
Low operating backpressure
Broad chemical stability
Wide CIP pH tolerance
Low nonspecific adsorption
Scalable downstream purification

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