Q Seplife BB Strong Anion-Exchange Medium, 1200-1800 cm/h (CAT#: STEM-BC-3163-ZJF)

This strong anion-exchange medium is designed for purification of proteins, nucleic acids, peptides, and endotoxin-containing process streams. It uses six-percent crosslinked agarose functionalized with quaternary ammonium groups. The permanently charged ligand provides strong anion-exchange functionality. Large particles provide high permeability and very low operating backpressure. The medium supports linear flow from 1200 to 1800 cm/h under the specified pressure condition. Broad chemical compatibility permits exposure to common buffers, denaturants, alcohols, and alkaline cleaning solutions. The matrix tolerates the stated steam-treatment conditions in water. Its scalable high-flow format can shorten processing time in downstream manufacturing.

Model: Q Seplife BB
Appearance: White spherical gel, odorless and tasteless
Type: Strong anion-exchange medium
Matrix: 6% crosslinked agarose
Ligand: Trimethylaminoalkyl quaternary ammonium group
Median particle size d50: 200 µm
Particle-size range: 100-300 µm
Ion-exchange capacity: 0.18-0.25 mmol Cl-/mL
Flow range: 1200-1800 cm/h at 0.1 MPa differential pressure and 25 cm bed height
Operating temperature: 4-30°C
Long-term pH stability: 2-12
Short-term CIP pH stability: 2-14
Chemical compatibility: Common aqueous buffers, 1 mol/L sodium hydroxide, 8 mol/L urea, 8 mol/L guanidine hydrochloride, 70% ethanol, and 30% isopropanol
Heat resistance: 121°C in water for 30 min
Storage: 20% ethanol at 4-30°C

Very high linear flow
Large permeable particles
Strong anion-exchange chemistry
Low operating backpressure
Broad chemical stability
Steam-resistant matrix
Suitable for endotoxin removal
Scalable downstream processing

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