Partial Thromboplastin Time (PTT) Test

Artificial organs and other medical device in contact with blood may cause thromboembolic complications. The partial thromboplastin time test is designed to determine whether a medical device is able to activate the intrinsic pathway of coagulation. This test provides important information about the hemocompatibility of a medical device that comes in contact with blood.

Fig. 1 Interaction between medical device and blood. (Nalezinková, 2020)

Standard of PTT Test

ISO 10993-4: 2002

Test Principle of PTT Test

PTT test is conducted by exposing the medical device or device extract to citrated human plasma, and then measuring the partial thromboplastin time. Medical device which is the activator of the intrinsic pathway of coagulation will shorten the partial thromboplastin time.

STEMart provides PTT test for the medical device including but limited to:

• External communicating devices in contact with circulating blood
• Blood storage and administration equipment
• Blood collection devices
• Extracorporeal membrane oxygenator system
• Hemodialysis/hemofiltration equipment
• Percutaneous circulatory support devices
• Catheters
• Guidewires
• Intravascular endoscopes
• Intravascular ultrasound
• Laser systems
• Retrograde coronary perfusion catheters
• Cell savers
• Device for absorption of specific substances from blood
• Donor and therapeutic apheresis equipment
• Implant devices placed largely or entirely within the vascular system
• Intra-aortic balloon pumps
• Leukocyte removal filter

STEMart provides partial thromboplastin time test to help manufacturer determine the ability of their product to activate the intrinsic pathway of coagulation. If you have additional questions about Partial Thromboplastin Time Test or would like to find out more about our services, please feel free to contact us.

References

• International Organization for Standardization. Biological evaluation of medical devices — Part 4: Selection of tests for interactions with blood. ISO 10993-4; (2002).
• Nalezinková, M. "In vitro hemocompatibility testing of medical devices." Thrombosis Research (2020).