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Pain Animal Model (CAT#: STEM-AE-0035-WXH)

Introduction

Pain is a complex neuropathological and subjective symptom with various causes. In recent years, in the field of pain and analgesia research, attention has been paid to the establishment of experimental models simulating acute, chronic or persistent pain in clinical patients. There are various methods for establishing pain models, generally, there are chemical stimulation models, physical stimulation models, neurogenic injury models, visceral traction pain models and other models. However, it is quite difficult for one model to reflect the pain caused by multiple etiologies at the same time. Experimenters need to select or establish a practical pain model for the purpose of the research.




Applications

• Study the pathogenesis and treatment of pain
• Drug development, drug screening and efficacy research

Procedure

• Chemical stimulation method
Pain caused by inflammatory stimulation, pain caused by drug stimulation.
• Physical stimulation method
Thermal stimulation, cold stimulation, electrical stimulation.
• Neurogenic Injury Model
Neuroma model, dorsal root ganglion chronic compression model (CCD), chronic ligation injury model (CCI), segmental spinal nerve ligation injury model, peripheral nerve freezing injury model, other neurogenic injury models.
• Visceral traction pain model
Use a balloon to dilate the stomach, pull the stomach with a string covered with a plastic tube, electrically stimulate the great visceral nerve, etc.

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