P-CLASS Molecular Interaction Analysis System

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P-CLASS SPR System

Where Sensitivity Meets Scale

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P-CLASS SPR System High-Performance Surface Plasmon Resonance Instrument for Molecular Interaction Analysis (STEMart Original)

The P-CLASS Series (P4 and P4 Pro) is a high-throughput molecular interaction analysis platform based on Surface Plasmon Resonance (SPR) technology. Designed for industrial-scale applications, the system integrates a micron-level fluidic control system, ensuring exceptional sensitivity and reliable performance across a wide range of complex biological samples.

With its innovative and intelligent software interface, the system supports parallel or independent operation of four injection needles, enabling both flexibility and efficiency in experimental design. Coupled with a broad portfolio of stable, high-quality sensor chips, the P-CLASS system empowers researchers and biopharmaceutical developers at every stage of the R&D pipeline - from early drug mechanism studies and high-throughput screening to advanced validation and rigorous quality control.

Applications

Drug Discovery: High-throughput screening and binding affinity analysis of small molecules and biologics.

Antibody Development: Epitope mapping, affinity maturation, and kinetic profiling of monoclonal antibodies.

Vaccine Research: Immunogenicity assessment and antigen-antibody interaction studies.

Biopharmaceutical Development: Lot-to-lot consistency testing, comparability studies, and process development.

Molecular Mechanism Studies: Real-time monitoring of protein–protein, protein–DNA/RNA, and protein–ligand interactions.

P-CLASS SPR System Applications - Drug Discovery, Antibody Development, Vaccine Research, Biopharmaceutical Development, and Molecular Mechanism Studies (STEMart Original)

Features

P-CLASS P4 Pro SPR System with Key Features: Medium-to-High Throughput, Flexible Operation, Ease of Use, High Sensitivity, and Scalable Performance (STEMart Original)

Medium-to-High Throughput: 4-needle, 8-channel configuration designed for standard microplate formats.

Flexible Operation: Freely select active injection needles; no need to fill unused positions.

Ease of Use: Modular "building-block" experimental design with a minimalist, intuitive software interface.

High Sensitivity: Integrated micron-level fluidic control ensures precise delivery and stable measurement.

Scalable Performance: Compatible with a wide range of sensor chips for diverse research and development needs.

Specifications

Parameter	P4	P4 Pro
Detection Principle	Surface Plasmon Resonance (SPR)
Data Information	Kinetics and affinity data (ka, kd, KD); binding specificity; screening, ranking, competition, concentration quantitation
Sample Types	Small molecules, proteins, nucleic acids, polysaccharides, lipids, cells, viruses, and other complex or clinical samples
Refractive Index Range	1.33–1.40
Flow Rate	1–100 μL/min
Injection Volume	1–300 μL
Injection Needles / Channels	4 independent injection needles, 8 detection channels (flow cells)
Reagent Capacity	2 × 96-well standard plates (shallow or deep), optional EP tubes	2 × 96- or 384-well standard plates (shallow or deep), optional EP tubes
Analysis Temperature	25 °C – 40 °C	4 °C – 40 °C
Sample Temperature Control	25 °C	4 °C – 40 °C
Data Acquisition Rate	1 Hz	1 Hz, 5 Hz, or 10 Hz
Operating Modes	1) Automatic injection 2) Manual injection
Detection Modes	1) Serial detection 2) Parallel detection
Reference Subtraction	Automatic double subtraction (online blank, zero concentration)
Single-Cycle Kinetics	Supported
Organic Solvent Correction	Supported
Sample Recovery (Fishing)	–	Supported
Epitope Analysis	Optional
Compliance	Optional 21 CFR Part 11
Dimensions (W × D × H)	650 × 550 × 650 mm
Weight	70 kg

Detection Performance

Parameter	Specification
Molecular Weight Range	No limitation for organic molecules
Baseline Noise	< 0.03 RU (RMS)
Baseline Drift (with reference subtraction)	< 0.03 RU/min
Association Rate Constant (ka)	1 × 10³ – 3 × 10⁹ M⁻¹·s⁻¹
Dissociation Rate Constant (kd)	1 × 10⁻⁶ – 0.5 s⁻¹
Affinity Range (KD)	1 × 10⁻³ – 1 × 10⁻¹⁵ M (fM – mM)

Whether you are accelerating drug discovery, advancing antibody development, or ensuring the highest standards in biopharmaceutical quality, the P-CLASS platform delivers the performance and flexibility you need. Contact us today to learn how P4 and P4 Pro can empower your projects and streamline your path to breakthrough results.

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