NOD-like Receptor Pathway Luminex Assay (CAT#: STEM-MB-0357-WXH)

As part of the innate immune response, NOD-like receptors have been the first to study the signal transduction pathway of bacterial invasion since their discovery. As a part of PRR, NOD-like receptors play a very important role in the innate immune response. They are not only expressed in innate immune cells, but also expressed in tumor cells. NOD-like receptors participate in anti-bacterial immune responses mainly through mediating NF-κB pathway, MAPK pathway and autophagy pathway. NOD2 receptors also mediate MAVS-IRF3/7-I type interferon signaling pathway to participate in antiviral immune response. In addition, , NOD-like receptors also have unique connection pathways with adaptive immune responses. NOD-like receptors also play a role in the occurrence and development of tumors, but in different tumors, NOD-like receptors play different roles. There are promoting and inhibiting.

To study the effect of each virus on NOD-like receptor signaling pathway
To study the regulation mechanism of NOD-like receptor signal pathway in disease
To study the effects of drugs or therapies on NOD-like receptor signaling pathways

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Detectable targets: MyD88, RIG-1, MDA5, cGAS, MAVS, TRAF3, TRAF6, IKK-α, NEMO, IkBa, p58, p65, TBK1, IKK-β, IRF3, IKK-c, STLNG, NLRC3, NLRX1, IFN-1, NFκB, RIG-1