Nerve GF (NGF) detection service (CAT#: STEM-MB-0255-WXH)

As the first neurotrophic factor discovered, NGF has the effect of promoting the survival and growth of nerve cells. After NGF binds to its high affinity receptor TrkA, the receptor TrkA phosphorylates to form a dimer. Phosphorylated TrkA binds to the SHC protein, and SHC acts as an adapter protein to connect to Grb containing SH2 and SH3 domains, and then binds to SOS to activate SOS. SOS activates the Ras protein, which in turn activates the RAS-induced signaling cascade. Activated Ras binds to Raf, which in turn activates MEK and ERK. After ERK enters the nucleus, it is involved in regulating cell proliferation.

NGF produced by the hippocampus and cerebral cortex can be retrogradely transported to the basal nucleus of the forebrain through cholinergic nerves to maintain the survival and function of cholinergic neurons.
NGF can inhibit the effects of the effector neurons nerve injury.
NGF can promote nerve regeneration and growth.
NGF can also affect the activity of immune cells, which in turn regulates the function of the immune system.
NGF inhibits the mitosis of certain tumors and promotes their benign differentiation.
NGF promotes the healing response of wound tissue and promotes wound healing.
NGF can also be used for the treatment of many diseases, such as delaying neurodegenerative diseases, or stimulating the growth of motor nerves in patients with spinal cord injury, accelerating burn recovery, reducing the side effects of chemotherapy and radiotherapy, treating pressure ulcers and eradicating corneal ulcers.

1. Process samples.
2. NGF detection (Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cell culture supernatant, cell lysate, cell culture medium, tissue homogenate, urine, tumor, etc.