MMC Large Scale HP Multimodal Medium, 60-90 mg mAb/mL (CAT#: STEM-BC-3152-ZJF)

This multimodal chromatography medium is designed for protein purification under high-salt conditions. It uses high-flow agarose microspheres as the base matrix. The medium combines weak cation-exchange, hydrophobic, and hydrogen-bonding interactions. This mixed-mode mechanism enables proteins to bind without extensive feed dilution. Samples with elevated conductivity can therefore be loaded directly under suitable process conditions. The 40 µm particles provide high resolution and efficient mass transfer. A monoclonal-antibody adsorption capacity of 60-90 mg/mL supports productive preparative purification. Broad chemical stability permits exposure to alkaline cleaning solutions, alcohol, acetate, and denaturants. The medium is suitable for capture, intermediate purification, and polishing of proteins.

Model: MMC Large Scale HP
Appearance: White spherical gel, odorless and tasteless
Matrix: Large Scale HP microspheres
Chromatography mode: Multimodal weak cation exchange
Interaction mechanisms: Cation exchange, hydrophobic interaction, and hydrogen bonding
Median particle size d50v: 40 µm
Monoclonal-antibody adsorption capacity: 60-90 mg/mL
Flow performance:>220 cm/h at 0.3 MPa
Long-term pH stability: 2-12
Short-term CIP pH stability: 2-14
Chemical compatibility: Common aqueous solutions, 1 M sodium hydroxide, 70% ethanol, 1 M sodium acetate, 6 M guanidine hydrochloride, and 8 M urea

Direct high-salt sample loading
Multimodal binding mechanism
High monoclonal-antibody capacity
Fine 40 µm particles
High-resolution purification
Broad chemical stability
Alkali-cleanable matrix
Reduced feed-dilution requirements

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