Measurement of Viscosity of Aqueous Solutions of Hypromellose by Rotating Viscometer Method (CAT#: STEM-PPA-0018-YJL)

Introduction

Cellulose derivatives have an irreplaceable role as pharmaceutical excipients with a wide use in the pharmaceutical industry, including manufacturing of current medicines and development of new dosage forms (DF) and modern pharmaceutical manufaturing processes. Hydroxypropyl methylcellulose, also called Hypromellose (HPMC) belongs to one of the most common hydrophilic cellulose derivatives used in the pharmaceutical industry and development of new oral and oromucosal matrix DF with controlled drug release. <br />HPMC molecule is based on a linear polysaccharide cellulose chain with ether-linked methoxyl and hydroxypropyl side groups. The types of HPMC differ by their chemical structure (substitution degrees and ratios), resulting molecular weight, viscosity and particle size. HPMC also provides a broad offer of viscosity grades and robust mechanism of drug release from various DF. Single-point comparison becomes topical in consequence to the pharmacopoeial requirement that the apparent viscosity of 2% hypromellose solution should be read at the shear rate of approximately 10 s(-1).