High-quality products
Reliable performance
IL-38 Detection (CAT#: STEM-MB-0304-WXH)
Introduction
IL-38 is one of the members of the IL-1 family, which is the same as other IL-1 family members. It lacks signal peptide and caspase-1 cleavage site. IL-38 is widely expressed in immune tissues, such as spleen, thymus, tonsils, etc., and the expression is particularly obvious in skin and tonsil B cells. The expression level is low in the heart, placenta and other non-immune tissues. There is a certain connection between IL-38 and inflammation.
Principle
The receptor of IL38 is IL-36R, and its binding ability is even stronger than IL-36Ra, so it plays a role in inflammation mainly through the IL-36Ra pathway. After the combination of Il-38 and IL-36R, it can inhibit the inflammatory pathway of NF-κB and mitogen-activated protein kinase（MAPKs）. NF-κB has an effect on the activation of the mammalian target of rapamycin (mTOR), which leads to the influence on the phosphorylation of signal transducer and activator of transcription（STAT）3, which ultimately affects the differentiation of Th17.
Applications
IL-38 plays an anti-inflammatory effect.
IL-38 can participate in many diseases(Crohn, arthritis, asthma, idiopathic pulmonary fibrosis and drug-induced pulmonary interstitial diseases).
IL-38 can inhibit endothelial cell proliferation and blood vessel formation stimulated by vascular endothelial growth factor (VEGF).
IL-38 can participate in many diseases(Crohn, arthritis, asthma, idiopathic pulmonary fibrosis and drug-induced pulmonary interstitial diseases).
IL-38 can inhibit endothelial cell proliferation and blood vessel formation stimulated by vascular endothelial growth factor (VEGF).
Procedure
1. Process samples.
2. IL-38 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.
2. IL-38 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.
Notes
Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.
Other recommended products
-
Vascular Endothelial GF (VEGF) detection service (CAT#: STEM-MB-0253-WXH)
-
IL-10 Detection (CAT#: STEM-MB-0279-WXH)
-
CXC Subfamily Detection Service (CAT#: STEM-MB-0259-WXH)
-
NF-kB Pathway Assay (CAT#: STEM-MB-0345-WXH)
-
LRRK2 Signaling Pathway Assay (CAT#: STEM-MB-0333-WXH)
-
EPO Detection (CAT#: STEM-MB-0267-WXH)
-
Epidermal GF (EGF) detection service (CAT#: STEM-MB-0252-WXH)
-
ERFG Pathway Assay (CAT#: STEM-MB-0348-WXH)
Wide range of applications
For various laboratory needs
Expert support
Professional service team
Fast delivery
Global shipping