IL-38 Detection (CAT#: STEM-MB-0304-WXH)

The receptor of IL38 is IL-36R, and its binding ability is even stronger than IL-36Ra, so it plays a role in inflammation mainly through the IL-36Ra pathway. After the combination of Il-38 and IL-36R, it can inhibit the inflammatory pathway of NF-κB and mitogen-activated protein kinase（MAPKs）. NF-κB has an effect on the activation of the mammalian target of rapamycin (mTOR), which leads to the influence on the phosphorylation of signal transducer and activator of transcription（STAT）3, which ultimately affects the differentiation of Th17.

IL-38 plays an anti-inflammatory effect.
IL-38 can participate in many diseases(Crohn, arthritis, asthma, idiopathic pulmonary fibrosis and drug-induced pulmonary interstitial diseases).
IL-38 can inhibit endothelial cell proliferation and blood vessel formation stimulated by vascular endothelial growth factor (VEGF).

1. Process samples.
2. IL-38 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.