IL-29 Detection (CAT#: STEM-MB-0296-WXH)

Name: IL-29 Detection
SKU: STEM-MB-0296-WXH
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Introduction

IL-29 is a member of the interferon family. It is mainly derived from Th17 cells, Th1 cells, and keratinocytes infiltrated into the skin, of which Th17 cells are the most important source. It is expressed at low levels in a variety of human organs, including blood, brain, lung, ovary, pancreas, pituitary, prostate, and testes. Almost all nucleated cells can express IL-29 when they are infected by certain viruses or stimulated by bacterial components. IL-29 has similar biological activities and functions as type I IFN in terms of anti-virus, anti-proliferation, anti-tumor, and immune regulation.

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Principle Applications Procedure Notes

Principle

IL-29 and IL-28 share a heterodimeric receptor complex composed of type II cytokine receptor family members IL-28R1 and IL-10R2, where IL-28R1 is the binding subunit and IL-10R2 is the auxiliary subunit. IL-28R1 is expressed at a high level in human gastrointestinal, respiratory system, heart and some glandular cells of the human body. IL-28R1 expression is relatively low in the brain, while IL-10R2 is commonly expressed in hematopoietic and non-hematopoietic stem cells. Like type I IFN, it activates the Jak- signal transducer and activator of transcription (STAT) signal transduction pathway. IL-29 first forms the IL28R1-IL29-IL10R2 ternary complex with its specific receptor complex, which is transduced by two receptor chains located in the cell. The signal is induced, and then the signal cascade is initiated. After a multi-step phosphorylation reaction, STAT2 is activated, leading to interferon-activated gene factor 3 complex (ISRE) interaction, thereby regulating gene transcription.