IL-24 Detection (CAT#: STEM-MB-0291-WXH)

The receptor of IL-24 is composed of two heterodimers, which are IL-20R1/IL-20R2, IL-22R1/IL-20R2, which belong to type II cytokine receptors. IL-20R is mainly expressed in normal skin keratinocytes and testis, and IL-20R1 is the main communicator of IL-20R activity. IL-22R1 is mainly expressed in normal liver and kidney tissues and various tumor cells. IL-24 can bind IL-20R2 alone, but its co-expression with IL-20R1 or IL-22R1 not only increases the affinity, but is also necessary for receptor activation. After IL-24 is combined with IL-20 and IL-22 receptor complex, it can activate JAK/ signal transducers and activators of transcription (STAT) signal pathway, and rapidly increase the phosphorylation transduction of tyrosine in JAK/STAT complex Signal, thereby regulating cell proliferation, migration and apoptosis.

IL-24 can inhibit the proliferation of many cancer cells by inducing apoptosis without damaging normal cells.
IL-24 can resist angiogenesis, immune regulation, and increase the sensitivity of radiotherapy and chemotherapy.

1. Process samples.
2. IL-24 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.