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HGF Signaling Pathway Assay (CAT#: STEM-MB-0372-WXH)
Introduction
Hepatocyte growth factor (HGF) is a multifunctional cytokine originally described as a mesenchymal-derived factor that regulates cell growth, cell motility, morphogenesis, and angiogenesis by activating its receptor, a transmembrane tyrosine kinase encoded by the c-Met proto-oncogene. hGF and c-Met are frequently co-expressed or overexpressed in a variety of human malignancies, including glioblastoma tumors and medulloblastoma; and their expression levels correlate with poor prognosis.
Principle
HGF an endogenous tissue repair factor, attenuates apoptosis in many primitive cell types. the HGF signaling pathway eliminates Ang II-induced apoptosis by inhibiting cytochrome c release, caspase-3 activation, and DNA fragmentation. RNA immunoprecipitation experiments show that HGF stabilizes Bcl-xL mRNA by increasing nucleotide binding to the 3' untranslated region of Bcl-xL mRNA, which is associated with the cytoplasmic localization of nucleotides. hGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK-dependent manner.
Applications
Study the impact of each clinical virus on the HGF signaling pathway
Research on the regulatory mechanism of HGF signaling pathway in medicine
Research on the regulatory mechanism of HGF signaling pathway in medicine
Procedure
• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology
Notes
Detectable targets: RTK, PI3K, TYK2, STAT1, STAT2, STAT3, PSGL1, TLR3, MAPK, TRAF5, MHC-II, RIP1, IRS2, TLR4, IRF3, PKR, icam1, Mda-5, MSK1, Rac1, CREB, mTOR, IRS1, MEKK1, Tak1, MYD88, TRAF6, ISRE, MEK6, IRF9, TRIF, JNK, SH2, Fas, p50, GAS, TNFR, IRAK4, p38MAPK, p38, SLP76, TRAF3, ISGF3, STAT5, MEK3, TLR9, TRAM, RIG-1, MSK2, Vav, IRF5, Rel, TCR, NFκB, PI3K, TBK1, CD3, NAP1
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Wide range of applications
For various laboratory needs
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