Heparin Seplife CL-6B Affinity Medium,>3 mg Antithrombin III/mL (CAT#: STEM-BC-3150-ZJF)

This heparin affinity medium is designed for purification of biological molecules that bind sulfated polysaccharides. It uses a crosslinked agarose matrix coupled with heparin. The ligand can interact with antithrombin III, coagulation factors, protein-synthesis factors, lipoproteins, interferons, and nucleic-acid-binding proteins. It is also applicable to restriction enzymes, thrombin, and thrombin-like proteins. Spherical particles provide uniform packing and convenient operation. The medium provides an antithrombin III adsorption capacity above 3 mg/mL. Broad chemical compatibility supports exposure to denaturants, alkaline solution, nonionic detergents, and glycerol. The matrix can withstand repeated heat treatment under the specified phosphate-buffer conditions.

Model: Heparin Seplife CL-6B
Appearance: Spherical gel, odorless and tasteless
Matrix: Seplife CL-6B
Ligand: Heparin
Shape: Spherical
Particle size: 45-165 µm
Pressure-flow range: 110-210 cm/h at 0.15 MPa
Antithrombin III adsorption capacity:>3 mg/mL
Ligand density:>5 mg/mL
Long-term pH stability: 4-10
Short-term CIP pH stability: 3-13
Heat resistance: 121°C in 0.02 M sodium dihydrogen phosphate at pH 7.5 for 30 min, up to 5 cycles
Chemical compatibility: 0.1 M sodium hydroxide, 0.05 M sodium acetate, 8 M urea, 6 M guanidine hydrochloride, nonionic detergents, and 10% glycerol

Heparin affinity ligand
>3 mg/mL antithrombin capacity
Broad protein-binding range
Crosslinked agarose matrix
Heat-treatment tolerance
Broad reagent compatibility
Stable spherical particles
Suitable for coagulation-factor purification

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