GENESYS 5000 Series Multi-well Gamma Counters, GENESYS (CAT#: STEM-AIAEPO-0150-LGZ)

The GENESYS 5000 series multi-well gamma counters are the most sophisticated gamma counters in the world. Available in 5- 10- 15- 20 or 25 wells - you'll find a model for your medium to high volume lab work.

The GENESYS 5000 series gamma counters contain advanced data reduction capabilities for calculating all versions of RIA-IRMA-Ratio and Screening Analysis. With the flexibility to independently select curve fit-response variables (transformations) and chart sheets, GENESYS 5000 enables you to fully handle a wide range of radioimmunoassays for clinical and research applications; from routine to esoteric.

Popular curve fitting ranges include: point-to-point-line-weighted line-cubic spline-universal and four-parameter logistic (4PL).

Response variables include: B/TC-B/B0-CPM-TC/B-B0/B-1/CPM-CPM/(Standard #)-CPM/(High Standard)-CPM/(TC-CPM) and (TC -CPM)/CPM.

The choice of standard curve axis is: linear-linear-semi-log-log-log-log-log-log-linear-log and log-linear.

The GENESYS 5000 series has the unique ability to count multiple isotopes, offering flexibility beyond conventional RIA. There may be ten different isotopes in the system.

Isotopes such as Cr51- ​​I131- In111- Na22- and Fe59 are some of the more common isotopes in today's laboratories.

With this flexibility - Schilling and blood volume are easy to run.

GENESYS integrates several functions to make this possible:

1. Cross Elimination Software

Makes it possible to calculate high-energy isotopes while still maintaining all the precision and accuracy of a single-well system. Any activity that might "crossover" from one well to the next is monitored and rejected without the need to "turn off" any other detectors.

2. Selectable window settings

Allows user to set upper and lower windows up to 1000 KEV. With this option - you can set a wide window to scan for any interfering isotopes that are not known.

3. Automatic overflow correction

Applied to each well to account for leakage of high-energy isotopes into low-energy windows when performing dual-label analysis. Any two isotopes can be counted simultaneously.

4. Unique crystal design

Enables GENESYS to count high-energy isotopes without the need for very large diameter detectors. There are many wells being counted simultaneously - plus our high efficiency engineered crystals greatly increase throughput.

With this variety of options - even the most demanding applications can be easily satisfied. Below is a brief description of each curve fitting algorithm:

Peer to peer:
This curve fit connects adjacent standard points with a straight line. This is a method of "connecting the dots" - very commonly used in older software packages for connecting particularly difficult data. This curve fit is best used when there are many standard points within the curve - or when the slope changes very drastically. This curve fit minimizes the curvature error.

Straight line:
This curve fit uses a straight line to fit all standard points within the curve. Therefore, this fit requires that all points on the curve be "linearized" first. This is usually achieved by using Logit-Log or /Bound type conversions. By linearizing first, data fitting errors are minimized.

Weighted straight line:
The curve starts with a straight line and then adds "weighting factors" as needed. These weighting factors are particularly helpful in minimizing the effects of spurious points further away from the most stable part of the curve (medium dose). The weighting factor changes the slope of the curve to maximally affect the mid-dose region of the curve.

Cubic spline:
A cubic spline is not actually a single curve, but a series of curve segments connected together in "knots". These knots are standard points. Therefore, the entire curve must pass exactly through the mean of each standard point. Cubic spline fitting is very commonly used in IRMA analysis, where a high number of standard points is typical. Due to the nature of cubic spline equations - the standard curve must contain at least 4 points to fill the equation.

General Curve:
The generic curve found in the Genesys 5000 series of gamma counters is an extension of the basic cubic spline, with some very unique differences. Generic curves take advantage of the statistical uncertainty of each standard point in the curve to allow a "range" to fit the curve, rather than forcing it through the mean. Because of this statistical "smoothing" capability, generic curves are capable of satisfying a wider range of data than standard cubic splines. Universal curves are particularly useful in IRMA assays involving very low count standard points at low doses. Since the uncertainty is largest near the end points of the curve and p

Condition: certified pre-owned

Crossover Elimination Software
Selectable Window Settings
Automatic Spilldown Correction
A Unique Crystal Design

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