EPO Detection (CAT#: STEM-MB-0267-WXH)

Erythropoietin is a colony-stimulating factor and belongs to the type I cytokine superfamily. The presence of sugar chains and sialic acid is a necessary condition for EPO to exert its biological activity in the body. In the fetus, EPO is mainly synthesized by the liver. The physiological function of EPO is mainly combined with the surface receptors (called EPOR) of Colony Forming Unit-erythroid, which promote the differentiation of erythroid directional stem cells into erythroblasts, hemoglobin synthesis of nucleated red blood cells, and release of red blood cells. An EPO molecule binds to the EPOR homodimer through two different sites, thereby activating EPOR, causing the activation of tyrosine kinase 2 (JAK2) in the cytoplasm, and then inducing signaling pathways including the transcriptional activation factor (STAT). Finally, it can inhibit the apoptosis of Colony Forming Unit-erythroid and promote their proliferation and differentiation.

Stimulates red blood cell production.
Recombinant human erythropoietin is used to treat anemia associated with renal insufficiency, acquired immune deficiency syndrome / AIDS itself or anemia caused by treatment, anemia associated with malignant tumors, and rheumatism Anemia and other anemia.
Treat anemia associated with renal insufficiency, anemia caused by acquired immunodeficiency syndrome itself or anemia caused by treatment, anemia associated with malignant tumors, anemia caused by rheumatism, and rheumatoid arthritis

1. Process samples.
2. EPO detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cell culture medium, tissue homogenate, etc.