Epilepsy Animal Model (CAT#: STEM-AE-0028-WXH)

Introduction

Epilepsy is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. Due to the different starting sites and transmission modes of abnormal discharges, the clinical manifestations of epileptic seizures are complex and diverse, which can be manifested as paroxysmal motor, sensory, autonomic, conscious and mental disturbances.<br />The predominant species and inducing methods for animal models of epilepsy are rodents and kindling, respectively. Classical kindling is the repeated electrical stimulation of limbic structures that leads to abnormal discharge and seizure attacks. Kindling is mainly divided into electrical and chemical types. Electrical kindling refers to the deep electrode implanted into the limbic brain region, e.g., the amygdala and hippocampus, or the topical stimulation of the corneas. Conversely, chemical kindling refers to the systematic injection of excitatory matter into the brain, leading to seizure attacks.