Dual Polarisation Interferometry(DPI) to study interactions between biological macromolecules (CAT#: STEM-MB-0160-WXH)

Introduction

Dual Polarization Interferometry (DPI) is a quantitative detection technology, especially in the research field of protein structure and the interaction between proteins and small molecules, breaking through the bottleneck of all other real-time measurement molecular dynamics technologies. A technology platform that is sensitive in measuring structural and conformational changes during intermolecular interactions.
DPI was invented based on the Thomas Yuong interference phenomenon of light. The light propagates through two parallel and adjacent thin-layer light-guiding media. After the light passes through the light-guiding medium, interference occurs to generate corresponding interference fringes. The dynamic interference fringe change information can be obtained by using an appropriate photodetector. The interference signal is calculated mathematically according to the Maxwell equation. The real-time changes in the density, thickness (molecular diameter or size), and surface concentration (mass) of the interface layer between the sample on the north side and other molecules can be obtained through conversion, so as to obtain the interaction relationship between interface molecules.