Determining the freezing point of pharmaceutical solution by differential scanning calorimetry technology (CAT#: STEM-PPA-0165-LJX)

When the physical properties of a substance change (such as crystallization, melting or crystal transformation, etc.) or a chemical reaction occurs, it is often accompanied by changes in thermodynamic properties such as enthalpy, specific heat, and thermal conductivity.
Differential scanning calorimetry (DSC) is to characterize the physical or chemical change process by measuring the change of the thermodynamic properties of substances. It is a thermal analysis method to measure the relationship between the power difference of the sample and the reference substance and the temperature under the condition of programmed temperature control.
Differential scanning calorimetry can easily achieve programmed temperature rise and temperature drop. The rate of heating and cooling can be set at will in a wide range, and the crystallization and melting process of the sample can be clearly displayed through the heat flow curve, so it is often used to determine the melting and crystallization temperature of various samples.

For determining the freezing point of liquid

1. Place the sample in the differential scanning calorimeter
2. Cooling: slowly add liquid nitrogen to the cooling tank to reduce the furnace temperature and fully freeze the sample
3. Heating up: take off the cooling tank, cover the outer cover of the furnace and the insulation cover, and heat up at a speed of 10℃/min
4. Stop the experiment after the sample is completely melted and the DSC heat flow curve returns to the baseline level

• Sample Type:
Pharmaceutical solution

The experiment should be repeated 3-5 times to ensure the accuracy of the results.