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Determination of Melting Point of Substituted Phenothiazine Derivatives by Open Capillary Method (CAT#: STEM-PPA-0081-YJL)

Introduction

Current treatments for depression either fail to producerecovery or induce unwanted side effects. So there is stilla large unmet clinical need. The heterocycliccompounds which contain nitrogen and sulphur possessan enormous significance in the field of medicinalchemistry. The main aims in the development of newantidepressants were greater efficacy, absence of sideeffects, lack of toxicity in over dose and earlier onset of action.




Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds