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Determination of Melting Point of Pyrazole Derivatives of Benzimidazoles by Open Capillary Method (CAT#: STEM-PPA-0111-YJL)
Introduction
The benzimidazole and pyrazole nucleus are an important structures in numerous natural and synthetic compounds and in medicinal chemistry. Benzimidazole derivatives are known to possess antifungal, antibacterial, antiviral anthelmintic analgesic, anti- inflammatory, anti-neoplastic, depressive, hypnotic, anti-pyretic and anti-spasmolytic, activities. Microwave assisted reactions have received great interest because of their simplicity in operation, enhanced reaction rates, products with high purity and better yields compared to those conducted by conventional heating.
Principle
Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
Applications
Chemical industry; Cosmetic/pharmaceutical industry
Procedure
1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
Materials
• Sample Type: crystalline compounds
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