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Determination of Melting Point of Manalogues of Curcumin Azo Ompound by Open Capillary Method (CAT#: STEM-PPA-0085-YJL)
Introduction
Since the dawn of humanity, natural products have been used in a traditional medicine to manage many illnesses affected on human health. Recently, many of marketed drugs have been originated directly or indirectly from these products. Also, current drug research is actively screened the possible pharmacological activities of many Ayruvedic and traditional Indian medicinal therapies. Among those being investigated, curcumin attracts a growing interest.Curcumin is the main natural polyphenol found in the rhizome of Curcuma longa (turmeric). This natural product has demonstrated a wide range of biological and pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, anti-diabetic, anti-malarial, antiprotozoal and antioxidant activities.
Principle
Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.
Applications
Chemical industry; Cosmetic/pharmaceutical industry
Procedure
1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.
Materials
• Sample Type: crystalline compounds
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