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Determination of Melting Point of Dihydropyrimidine by Open Capillary Method (CAT#: STEM-PPA-0065-YJL)

Introduction

In recent years dihydropyrimidines and its derivatives showed significant applications due to their pharmacological and therauptic properties. Compounds containing dihydropyrimidinecore unit shows biological activities such as antitubercular agent anti-inflammatory agents,antiviral,antibacterial, antimalarial, antihypertensive agents, cytotoxic, calciumchannel antagonists etc.<br />Numerous inorganic oxides such metal oxides have been reported to synthesis of various organic compounds and derivatives. They have been found to have better catalytic activities than the conventional type of catalyst and have wide applications in synthesis due to shorter reaction time such as in Bigenelli type reactions. dihydropyrimidine was synthesized using gadolinium oxide (Gd2O3) as a catalyst.




Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds