Determination of Melting Point of di-substituted 2-(ɑ-hydroxy benzyl) Bezimidazole Derivatives by Open Capillary Method (CAT#: STEM-PPA-0087-YJL)

Introduction

Literatures survey that benzimidazole derivatives can be synthesized by various routes. Synthesis of new benzimidazoles of new compounds that can be used as medicines for prophylamine and curing diseases. Benzimidazole nucleus has been reported to posses antimicrobial and antifungal activities. This benzimidazole possessing free imino hydrogen are tautomeric systems. The two possible tautometic forms of benzimidazoles( and of those of its derivatives possessing a plane of symmetry) are identical and a definite assignment of structure is possible. Examples are 2-methyl, 5,6-dimethyl and 4,7- dimethyl benzimidazoles The benzimidazoles are high melting and high boiling solids.

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds

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