Determination of Melting Point of Azomethines by Open Capillary Method (CAT#: STEM-PPA-0077-YJL)

Introduction

Azomethines are generally known as Schiff bases to honour Hugo Schiff, who synthesized such compounds. These are the compounds containing characteristic -C=N- group. Several methods have been reported for the preparation of azomethines. Schiff bases can be synthesized from an aromatic amine and a carbonyl compound by nucleophilic addition forming a hemiaminal, followed by a dehydration to generate an imine. They are well known intermediates for the preparation of azetidinones, thiazolidinones, oxadiazolines and many other derivatives. Azomethines exhibit a wide range of pharmacological activities like antimicrobial, antiparasitic, anti-inflammatory, anticancer etc. Pyrimidine and their derivatives posseses several interesting biological activity such as antimicrobial, antitumor, antifungal activities.