Chemical analysis in traditional Chinese medicines by ion mobility mass spectrometry (CAT#: STEM-ST-0078-LJX)

Introduction

In recent years, with the development of IM-MS technologies, IM-MS has become more widely employed in chemical analysis in traditional Chinese medicines (TCMs). Firstly, IM-MS was been successfully used in the separation of complex TCMs complex extract from interfering isobaric species. Secondly, IM-MS also offers new types of MS/MS fragmentation modes, and the combination of IM separation and fragmentation modes enables the acquisition of more specific and detailed fragment ion spectra. Thirdly, the collision cross-section is introduced by IM-MS, which is a unique physicochemical property of a component. Related data post-processing strategies based on experimentally derived collision cross-section values have been continuously developed in recent years to make full use of the collision cross-section values, these data post-processing strategies include collision cross-section database matching, theoretical collision cross-section values matching, machine-learning-based collision cross-section values prediction matching, mass-to-charge ratio versus collision cross-section correlation trend lines and so on. In doing so, these diverse strategies can greatly enhance the reliability and accuracy of the structural annotation of TCM compounds.