CDK Signaling Pathway Assay (CAT#: STEM-MB-0312-WXH)

The CDK signaling pathway includes two types of regulation: positive regulation and negative regulation.
Positive regulation of CDK phosphorylation: located at position 160 of the conserved threonine residues in the amino acid sequence of CDK2. This residue is hidden in the T loop. After phosphorylation, the t-loop structure changes, the affinity of cyclin to CDK increases, and the CDK complex is activated.
Negative regulation of CDK phosphorylation: The inhibition of CDK complex activity shows that the simultaneous phosphorylation of the 14th treponin residue and the 15th tyrosine residue inhibits the activity of the CDK complex.

Study the impact of each clinical virus on the CDK signaling pathway
Research on the regulatory mechanism of CDK signaling pathway in medicine
Study the effects of drugs or therapies on the CDK signaling pathway

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Detectable targets: RTK, PI3K, TYK2, STAT1, STAT2, STAT3, TNFR, ISGF3, MSK2, PI3K, TBK1, Vav, STAT5, IRAK4, JNK, MYD88, Rac1, TLR4, CREB, IRF3, MAPK, NAP1, Rel, TLR9, MHC-II, IRS1, MEK6, p50, SLP76, TRAM, TCR, icam1, Mda-5, NFκB, RIG-1, TRAF3, GAS, IRF9, MEKK1, p38, RIP1, TRAF5, PSGL1, IRS2, MSK1, TLR3, Tak1, TRIF, CD3, IRF5, MEK3, p38MAPK, SH2, TRAF6,, Fas, ISRE, mTOR, PKR