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The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. <br />Quantifying the strength of the interactions between peptides and major histocompatibility complex (MHC) proteins is important in the identification of T cell epitopes and evaluating the consequences of naturally occurring or engineered peptide modifications.