Analysis of Micrometer and Submicrometer Subvisible Particles in Protein Therapeutics by Suspended Microchannel Resonator (SMR) (CAT#: STEM-PC-0131-CJ)

The SMR uses the principle that the resonating frequency of an oscillating cantilever (visualize a diving board in motion) is proportional to its mass. The SMR is made up of a cantilever containing a tiny fluidics channel surrounded by a vacuum. When a single cell flows through the channel inside the cantilever, the resonant frequency of the cantilever changes in proportion to the mass of the cell.

Biochemistry; Biopharmaceuticals; Pharmaceuticals; Biomedical

1. Sample preparation.
2. The sample solution flows through the microchannel in the resonant cantilever, and mechanical resonance occurs to obtain data.
3. Analyse the data.

• Sample: Particle-based APIs (e.g., VLPs, liposomes, polymeric nanoparticles), Virus Particle, Protein Formulations
• Equipment: Suspended Microchannel Resonator (SMR)

1. The SMR is a microelectromechanical systems (MEMS) device that can weigh individual cells to a precision better than one part in 1,000.
2. Using a suspended microchannel resonator, researchers can measure the relative positions of tiny particles as they flow through a fluidic channel.