Analysis of Biopharmaceutical Lyophilizate Residual Moisture by Near Infrared Spectroscopy (NIR) (CAT#: STEM-B-0417-CJ)

Introduction

The development of a lyophilized formulation and the corresponding freeze-drying process go hand in hand. An in-depth characterization of the freeze-dried powder during process development provides all relevant data require to optimize critical process parameters. Freeze-drying has advanced to the point where it is a common practice for biopharmaceuticals, including blood plasma and vaccines. Lyophilization is still a method of choice for preservation of the growing list of biopharmaceutical products.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

NIR spectroscopy is a method that makes use of the near-infrared region of the electromagnetic spectrum (from about 700 to 2500 nanometers). By measuring light scattered off of and through a sample, NIR reflectance spectra can be used to quickly determine a material’s properties without altering the sample. NIR converts measured data into actionable information to help optimize processes or improve research. Capable of examining irregular surfaces with the same ease as a carefully prepared sample, NIR is non-destructive, and requires little or no sample preparation. It can also be used to analyze multiple constituents in a single scan.

Applications

Biopharmaceutica

Procedure

1. Prepare the sample.
2. Place the sample into the Near-infrared (NIR) spectroscopy instrument.
3. Analyze the data.

Materials

• Sample: Proteins, Peptides, Nucleic acids, Naturally-occurring compounds & more
• Equipment: Near Infrared Spectroscopy (NIR)

Other recommended products

Analysis of Biopharmaceutical Lyophilizate Appearance and Structural State by X-Ray Microscopy (XRM) (CAT#: STEM-B-0424-CJ)
Analysis of Biopharmaceutical Lyophilizate Residual Moisture by Vapor Pro Moisture Analyzer (CAT#: STEM-B-0418-CJ)
Analysis of Biopharmaceutical Lyophilizate Residual Moisture by Thermogravimetric analysis (TGA) Method (CAT#: STEM-B-0416-CJ)
Analysis of Biopharmaceutical Lyophilizate Residual Moisture by Headspace Moisture Analysis (HMA) / Frequency Modulation Spectroscopy (FMS) (CAT#: STEM-B-0413-CJ)
Analysis of Biopharmaceutical Lyophilizate Residual Moisture by Loss on drying (LOD) Method (CAT#: STEM-B-0415-CJ)
Analysis of Biopharmaceutical Lyophilizate Specific Surface Area by Mercury Intrusion Porosimetry (CAT#: STEM-B-0422-CJ)
Analysis of Biopharmaceutical Lyophilizate Specific Surface Area by Gas Adsorption Analysis Based on Brunauer–Emmett–Teller (BET) Theory (CAT#: STEM-B-0421-CJ)
Analysis of Biopharmaceutical Lyophilizate Specific Surface Area by Micromeritics' TriStar II (CAT#: STEM-B-0423-CJ)