Analysis of Aβ40 (4G8) (Human, Mouse, Rat) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0042-LGZ)

Introduction

The misfolding of natively folded proteins into amyloid aggregates is associated with a broad range of pathology in humans. One of the most widely studied amyloidogenic peptides is the amyloid-β (Aβ) peptide. The aggregation of this peptide is known to be associated with the progression of Alzheimer disease (AD), which is the most common cause of dementia today. Deposition of amyloid β (Aβ) in the brain is a pathological hallmark of Alzheimer's disease. There are two major isoforms of Aβ: the 42-residue Aβ42 and the 40-residue Aβ40. The only difference between Aβ42 and Aβ40 is that Aβ42 has two extra residues at the C-terminus.