Analysis Ligand-receptor Binding of Biopharmaceutical Compounds by Fluorescence Resonance Energy Transfer (FRET) (CAT#: STEM-B-0394-CJ)

Introduction

Biological activity is, besides the safety of the therapy, the most important aspect of a drug product or therapy. Thus, a major goal of formulation development is to maintain the functionality of the therapeutic compound inside its formulation throughout its shelf-life.<br /><br />Binding of a ligand to a receptor changes its shape or activity, allowing it to transmit a signal or directly produce a change inside of the cell. Stages of signal transduction: ligand-receptor binding, signal relay, response.